目的：研究舒痛安胶囊(STAC)的益气、补血、止痛 、镇静和催眠作用。

方法：采用限食性气虚、急性出血性血虚小鼠模型，热板法、扭体法、自主活动和戊巴比妥钠睡眠时间试验方法。

结果：STAC有显著对抗气虚小鼠的体重、血红蛋白(Hb)含量和T淋巴细胞ANAE阳性率的下降，显著抑制限食所致的胸腺萎缩，显著提高急性失血性“血虚”小鼠的Hb含量，减少醋酸性扭体反应次数和延长热刺激致痛的潜伏期，减少小鼠自主活动时间和抬前脚次数，协同戊巴比妥钠促进小鼠睡眠。

结论：实验结果提示其具有益气、补血、止痛、镇静催眠作用。

关键词：舒痛安胶囊；益气补血；止痛；镇静催眠

中图分类号：R965  文献标识码：A  文章编号：1001-1528(2000)12-0853-03

舒痛安胶囊的作用：
   1、扶正祛邪，解毒排毒，解痉镇痛，镇心安神，活血化瘀，强身健体等多部位、多活性、多靶点的复方中药作用。 
    2、亚意识抑制中枢，对前三天剧烈的戒断反应不能感受，在无痛苦下戒毒。
    3、调节戒断时的脑内蓝斑核异常放电，改变脑内催产素含量，减轻对吗啡依赖和产生耐受。
    4、对抗戒断时出汗、流泪、流涕等生理性戒断反应。
    5、改善微循环及组织灌注，加快毒品排泄。
    6、非替代作用，不成瘾。

Pharmacological Study on Shutongan Capsule

LI Kai-shuang，ZHOU Long-qiang，XIE Tang-gui，LI Chui-hong，CHEN Yi

(Guangxi Institute of Traditional Chinese Medicine and Pharmaceutical Sciences,  Nanning 530022, China)

Abstract：

Objective：To study the effects of Shutongan Capsule  (STAC) on supplementing the vital energy, enriching the blood, alleviating pain , sedation and hypnosis.

Methods： The mouse models of vital energy-deficiency caused by limiting food, blood-deficiency caused by acute hemorrhagic symptoms, the methods o f hot-plate, writhing, autonomic locomotions and sleep-promoting test in combination with pentobarbital sodium were used.  

Results： STAC had the pharmacological actions counteracting the lowering in body-weight, hemoglobin (Hb) con tents and positive reaction rate on acid α-naphthyl acetate esterase (ANAE) of  lymphocyte of mice with vital energy -deficiency, inhibiting atrophy of thymus of mice by limiting food and increasing the Hb contents of mice with blood-deficiency caused by acute hemorrhagic symptoms markedly, decreasing the frequency of body torsion induced by acetic acid  (HAC) and prolonging the incubation period of pain induced by heat stimulation  in mice, reducing the autonomic activity time, and the fequency of lifting fore paws, and promoting sleep in combination with Nembutal in mice.  

Conclusion：  It suggestes that STAC have effects of supplementing the vital energy, enriching the blood, alleviating pain, sedation and hypnosis. 

Key words： Shutongan Capsules； Supplementing the vital energy  and enriching the blood; Alleviating pain; Sedation and hypnosis