KEY WORDS :upr enorphine;narcotic dependence;drug evaluation

    ABSTRACT

    AIM:To survey and assess the drug dependence and abuse potential liability of buprenorphine among opiate abusers.

    METHODS:Subjects of opiate dependence with history of buprenorphine use for 3 d at least were urveyed by interview.Physical dependence of buprenorphine was assessed using 30 items opiate withdrawal scale (OWS),which composed of 30 symptoms/signs.A 4-point scale was used to rate each symptoms/signs: zero (0),mild (1),moderate (2),and severe (3).Subjects were asked to rate their symptoms according to severity of previous experienced buprenorphine withdrawal.The estimate of the degree of subjective euphoria for buprenorphine was assessed using visual analogue scale (VAS).

    RESULTS:Subjects 1235 who met the r esearch criteria cases completed this survey in  multi-detoxification treatment centers.The main initial purposes of buprnorphine use were detoxification (77.4%)and protracted abstinence treated (26.6%)respectively.The scores of OWS of buprenorphine wer e between 0.2 to 1.3;The mean scor es of OWS in 3 different categories of
frequency of buprenorphine use on "continuous use","un-continuous use",and "sometimes continuous,some-times un-continuous"were 0.910.9,0.410.5,and 0.7 士0.4,respectively (F=70.846,尸<0.05).The degree of subjective euphoria for buprenorphine was slight to sub-moderate (mean score of VAS was 27 tou t 124 mm).The mean scor es of VAS in different routes of buprenorphine administration of sublingual and injection wer e (24123) mm and (27 124)mm,r espectively.No significant differ ence was found between sublingual and injection use of buprenorphine (u=1.516,P>0.05).

    CONCLUSION:Both physical and psychic'dependence of buprenorphine were low.

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